Fig. 4: Antibody landscapes for each serum
group. Colored surfaces show the GMT antibody landscapes for
the different serum groups, light gray surfaces show the landscapes for
individual sera. Gray impulses show the height of the GMT for a specific
variant, after accounting for individual effects as described in
Materials and Methods (which would otherwise bias the GMT for variants
not titrated against all sera). The base x-y plane corresponds to the
antigenic map shown in Fig. 3. The vertical z-axis in each plot
corresponds to the titer on the log2 scale, each two-fold increment is
marked, starting from a titer of 20, one unit above the map surface. The
gray horizontal plane indicates the height of a titer of 50, as a
reference for judging the landscapes against various estimates of
neutralizing antibody correlates of protection. The number of sera
included for the calculation of the landscapes are A) D614G sera (n=15),
B) B.1.1.7 sera (n=14), C) B.1.351 sera (n=19), D) P.1 sera (n=17), E)
B.1.617.2 sera (n=29), F) B.1.526+E484K sera (n=8), G) B.1.637 sera
(n=3), H) C.37 sera (n=10), I) BA.1 sera (n=4), J) BA.2 sera (n=1), K) 4
weeks post 2x mRNA-1273 sera (n=67), L) >3 months post 2x mRNA-1273
sera (n=16), M) 4 weeks post 3x mRNA-1273 sera (n=26), N) >3 months
post 3x mRNA-1273 sera (n=13), O) 4 weeks post 2x mRNA-1273.351 sera
(n=9).